Does anyone know if the brown skin discoloration that can occur with Venofer extravasation is permanent?
Our pharmacy doesn't know and all I see on literature is that it can occur.
Chris Thomas
Fairview Hospital
Cleveland, Ohio
Does anyone know if the brown skin discoloration that can occur with Venofer extravasation is permanent?
Our pharmacy doesn't know and all I see on literature is that it can occur.
Chris Thomas
Fairview Hospital
Cleveland, Ohio
There is no mention of Venofer being a vesicant medication in Gahart's Intravenous Medications. So "extravasation" would not be the right term. I have not found any other reports of this drug being associated with tissue destruction either, so leakage from the vein would be infiltration according to the INS Standards and those definitions. Also Gahart's book does not make any mention of the tissue discoloration, so can't answer your question. The pH of this drug is 10.5 to 11.1, so it should not be infused thorugh peripheral veins according to INS SOP. Upper level pH is 9 through PIV. Lynn
Lynn Hadaway, M.Ed., RN, NPD-BC, CRNI
Lynn Hadaway Associates, Inc.
PO Box 10
Milner, GA 30257
Website http://www.hadawayassociates.com
Office Phone 770-358-7861
Note what is pasted from the package insert for Venofer. Injection Site Extravastion. I found this on the manufacturer's website. Sorry this didn't paste well. Just google venofer and look at the full prescribing information.
Mary Penn RN
Treatment-Emergent Adverse Reactions Reported in
the Rate for Venofer Exceeds the Rate for Comparator
Adverse Reactions
(Preferred Term)
HDD-CKD NDD-CKD PDD-CKD
Venofer
(N=231)
%
Venofer
(N=139)
%
Oral Iron
(N=139)
%
Venofer
(N=75)
%
≥ 2% of Study Populations and for whichEPO* Only
(N=46)
%
Subjects with any adverse reaction
78.8 76.3 73.4 72.0 65.2
Ear and Labyrinth Disorders
Ear Pain
0
2.2
0.7
0
0
Eye Disorders
Conjunctivitis
0.4
0
0
2.7
0
Gastrointestinal Disorders
Abdominal pain
Diarrhea
Dysgeusia
Nausea
Vomiting
3.5
5.2
0.9
14.7
9.1
1.4
7.2
7.9
8.6
5.0
2.9
10.1
0
12.2
8.6
4.0
8.0
0
5.3
8.0
6.5
4.3
0
4.3
2.2
General Disorders and
Administration Site Conditions
Asthenia
Chest pain
Feeling abnormal
Infusion site pain or burning
Injection site extravasation
Peripheral edema
Pyrexia
2.2
6.1
3.0
0
0
2.6
3.0
0.7
1.4
0
5.8
2.2
7.2
0.7
2.2
0
0
0
0
5.0
0.7
2.7
2.7
0
0
0
5.3
1.3
0
0
0
0
0
10.9
0
Infections and