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Christine Thomas
Venofer extravasation

Does anyone know if the brown skin discoloration that can occur with Venofer extravasation is permanent?

Our pharmacy doesn't know and all I see on literature is that it can occur.

 

Chris Thomas

Fairview Hospital

Cleveland, Ohio

lynncrni
 There is no mention of

 There is no mention of Venofer being a vesicant medication in Gahart's Intravenous Medications. So "extravasation" would not be the right term. I have not found any other reports of this drug being associated with tissue destruction either, so leakage from the vein would be infiltration according to the INS Standards and those definitions. Also Gahart's book does not make any mention of the tissue discoloration, so can't answer your question. The pH of this drug is 10.5 to 11.1, so it should not be infused thorugh peripheral veins according to INS SOP. Upper level pH is 9 through PIV. Lynn

Lynn Hadaway, M.Ed., RN, NPD-BC, CRNI

Lynn Hadaway Associates, Inc.

PO Box 10

Milner, GA 30257

Website http://www.hadawayassociates.com

Office Phone 770-358-7861

mary-ivt
Venofer Infiltration/extravasation


Note what is pasted from the package insert for Venofer.  Injection Site Extravastion.  I found this on the manufacturer's website.  Sorry this didn't paste well.  Just google venofer and look at the full prescribing information. 

Mary Penn RN

Treatment-Emergent Adverse Reactions Reported in

the Rate for Venofer Exceeds the Rate for Comparator

Adverse Reactions

(Preferred Term)

HDD-CKD NDD-CKD PDD-CKD

Venofer

(N=231)

%

Venofer

(N=139)

%

Oral Iron

(N=139)

%

Venofer

(N=75)

%

2% of Study Populations and for which

EPO* Only


(N=46)

%

Subjects with any adverse reaction


 

78.8 76.3 73.4 72.0 65.2

Ear and Labyrinth Disorders


Ear Pain

0

2.2

0.7

0

0


Eye Disorders


Conjunctivitis

0.4

0

0

2.7

0


Gastrointestinal Disorders


Abdominal pain

Diarrhea

Dysgeusia

Nausea

Vomiting

3.5

5.2

0.9

14.7

9.1

1.4

7.2

7.9

8.6

5.0

2.9

10.1

0

12.2

8.6

4.0

8.0

0

5.3

8.0

6.5

4.3

0

4.3

2.2


General Disorders and

Administration Site Conditions


Asthenia

Chest pain

Feeling abnormal

Infusion site pain or burning

Injection site extravasation

Peripheral edema

Pyrexia

2.2

6.1

3.0

0

0

2.6

3.0

0.7

1.4

0

5.8

2.2

7.2

0.7

2.2

0

0

0

0

5.0

0.7

2.7

2.7

0

0

0

5.3

1.3

0

0

0

0

0

10.9

0

Infections and

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