I recently was called to restart IV's on two patients who had had infiltrations during infusion of IVPB meds via 22g PIV's in small hand and forearm veins. I am suspicious that the infiltrations were the result of the 400 to 600 ml/hr infusion rates but can find no references to support recommending slowing the pharmacy suggested infusion rate based on consideration of the size or quality of the veins in use. It would seem to me that this is an intuitive thing, but with overworked bedside nurses, I'm lucky if I can get them to ensure initial patentcy, let alone think about flow rates. Anyone know of any evidence or supporting documents? Thoughts?