I wanted to ask what is your practice and decision pathway for VAD inserted for long term Abx. Currently in our trust we are experiencing increase in failure rate of midlines inserted for that indication. As far as we can check pH of drugs being given is not outside recommended range (5 - 9) but only thing which comes to my mind at the moment is chemical thrombophlebitis from long term infusion to peripheral vein. Those leaks from insertion site (assumed VTE) occur despite good position of the line tip and following all ZIM guidelines. MAGIC decision tool recommends PICC for abx course longer than 2 weeks. What is your practice? There was a suggestion that it may be an issue with the brand of lines we use but we can not see why it would be the case.