I work at a 600+ bed hospital. We are trying to develop a program aimed at care and maintenance as well as look at everything that we do related to central lines. Does anyone know of any successful programs or of hospitals of similar size with the same situation that have had success lowering their rates? We switched to Cook antimicrobial PICC's over a year ago in an effort to lower the rates but they have not helped and they seem to clot more easily. Our cathflo usage is way up. We are very frustrated!!