Does anyone manage infiltration/extravasation? Is there any policy/protocol to aspirate fluid/blood from a infiltrate after the needle has been removed. Had an incident where heparin was infiltrated twice in the same area, nurse removed needle without aspirating heparin, thus created a huge blood/heparin blister (approx 50ml) that was causing sever pain to the patient hand. While waiting for the MD to assess the situation, the blister burst and the patient immediately had relief from the decompressed pressure. As a CRNI nurse I am called upon for all kinds of vascular issues, not just infusion related. I know the best practice is to leave the unroofed blister intact, But sometimes the best medicine is to aspirate. We have policies for infiltration/extravasation that stated to aspirate med/blood via the catheter,is it still ok to do the same after the iv catheter has been removed? Which means to stick with a needle to aspirate? In this case pressure could have been relieved much earlier which would have decrease the pain level and increase patient comfort. Compartment syndrome could have been an issue in this situation if the blister would not have unroofed while waiting for the MD.