Literature review from INS and other sources list Zosyn (pippercillin/tazobactam) as a vesicant, yet I can't figure out why.
According to my information, both the 2.25-4.5 and 3.375 gm solutions have a pH (in D5W and NS) between 5.1 and 6.7 and with osmolarity of 270-330 for the ones diluted in D5W and 445 for that in NS. How then, with "acceptable" ranges, is this considered a vesicant?
Lyn, can you shed some light on this?
Thanks in advance!