Do you flush the PICC line half way into a blood transfusion? I have no data to support but I believe it should be flushed. Hopefully I can do a little study at the hospital to find out. A typical PRBC is transfused over 2-4 hours. Even though blood is pumped (or dripped) in thru the PICC continuously but with that extended period of time there must be clotting happening inside the PICC. A good NS flush half way into the transfusion will help keep the PICC wide open. What does everybody think?