Our outpatient center currently has a Von Willibrand's patient receiving Factor VIII BID for 4 weeks post-op via a Solo PICC. We have had complete occlusion at least once and problems with blood return and sluggish flushing ongoing. We have used Cath Flo at least twice so far in his 2 weeks of treatment. We flush with 20cc saline after the infusion. We don't have any experience giving this over an extended period like this through a PICC. It does make sense if you ar giving clotting factor that it might clot around your PICC. I think it is crazy & expensive to keep giving Cath flo. Does anyone have experience with this scenario? Should we use heparin to lock the line?Thanks for any input!!