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From some info I received from Cubist Pharmaceuticals:

"Daptomycin is manufactured to ensure that the pH of the reconstituted product is between 4.0 and 5.0." Chart provided gives pH of 4.5 when reconstituted with 0.9% saline,4.59 to 4.84 using LR and 4.8-5.0 using sterile water for injection.

Osmolality varies with concentraion and diluent,from 265 (5mg/ml in LR) to 364 (50mg/ml in NS) to 38-47 using SWFI.

The document further states: "Daptomycin may be administered via a peripheral or central intravenous line,in part,based upon the health care provider's intravenous administration guidelines and/or policies. Clinical experience with daptomycin has been primarily with peripheral intravenous administration."

The prescribing information found on the product's website lists 'injection site reaction' from Phase 3 data at a rate of 5.8% ,comparing to Vanco at 7.7%.

I suggested that the company include this information in their prescribing information as it seems to be an oft-asked question in the vascular realm.

Thanks for posting this. I

Thanks for posting this. I never heard from the rep who was supposed to get this to me. This pH would mean that it should be infused through a central line. How long is the typical course for this drug in your experience? Thanks,Lynn 


Lynn Hadaway, M.Ed., RN, BC, CRNI

Lynn Hadaway, M.Ed., RN, BC, CRNI

Lynn Hadaway Associates, Inc.

126 Main Street, PO Box 10

Milner, GA 30257


Office Phone 770-358-7861

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