"Daptomycin isÂ manufactured to ensure that the pH of the reconstituted product is between 4.0 and 5.0." Chart provided gives pH of 4.5 when reconstituted with 0.9% saline,4.59 to 4.84 using LR and 4.8-5.0 using sterile water for injection.
Osmolality varies with concentraion and diluent,from 265 (5mg/ml in LR) to 364 (50mg/ml in NS) to 38-47 using SWFI.
The document further states: "Daptomycin may be administered via a peripheral or central intravenous line,in part,based upon the health care provider's intravenous administration guidelines and/or policies. Clinical experience with daptomycin has been primarily with peripheral intravenous administration."
The prescribing information found on the product's website lists 'injection site reaction' from Phase 3 data at a rate of 5.8% ,comparing to Vanco at 7.7%.
I suggested that the company include this information in their prescribing information as it seems to be an oft-asked question in the vascular realm.