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Cathflo Activase

Anyone know the half life of activase of the top of your head?


Half life of alteplase is
Half life of alteplase is approximately 5 minutes
Thank you!
Thank you!

Carol Sweeney, CRNI; Principal and Vice President of Clinical Operations First Choice Health Care Systems, LLC.

 In patients with acute

 In patients with acute myocardial infarction administered 100 mg of Activase as an accelerated intravenous infusion over 90 minutes, plasma clearance occurred with an initial half-life of less than 5 minutes and a terminal half-life of 72 minutes. Clearance is mediated primarily by the liver.

When Cathflo Activase is administered for restoration of function to central venous access devices according to the instructions in DOSAGE AND ADMINISTRATION, circulating plasma levels of Alteplase are not expected to reach pharmacologic concentrations. If a 2 mg dose of Alteplase were administered by bolus injection directly into the systemic circulation (rather than instilled into the catheter), the concentration of circulating Alteplase would beexpected to return to endogenous circulating levels of 5−10 ng/mL within 30 minutes.1 



Mari Cordes, BS RN 

Nurse Educator IV Therapy
Fletcher Allen Health Care, Burlington VT
Educator, Bard Access Systems 

Mari Cordes, BS RNIII VA-BC
Vascular Access Department
University of Vermont Medical Center

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