We have a patient who has PICC where the tip lies in the axillary vein. Further distal, there is occlusion of the brachiocephalic vein from the extrinsic compression from the tumor. The physician reported that there seems to be cutaneous collaterals on the chest wall that bypass the SVCO through drainage via IVC. Patient needs urgent chemo - 2 of the chemo are vesicant. The physician stated that it is safe to administer the vesicant chemotherapy via the existing PICC and don't think it is necessary to insert femoral PICC. Is this approach safe? Appreciate your expert advice.