Hello. At my institution we infuse many different drugs, Chemo and no-chemo. I have heard anecdotally of incidents where a patient was receiving Paclitaxel or Docetaxel and while the the medication was being Run Down (which for us is to fill the IV tubing with the medication, to the VAD, before starting the actual infusion) the patient experiences a hypersensitivity reactine before the medication "reaches" the patient based on the tubing volume. Our tubing is 25cc in volume. Even if we run down 20cc (5cc short of the patient) there are reported reactions. Do you see this in your practice, and if so, has it been investigated to understand that happens? What drugs has it occured with? We use Alaris pumps and tubing. Thank you.