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My slides from my AVA 2006 presentation on Infiltration and Extravasation states that hyaluronidase should be used with 1-2 hours but may be effective within 12 hours. I can not immediately tell you the exact reference but have attached my complete reference list from that presentation. Lynn

When writing the system contrast policy, I contacted our Clinical Pharmacist and asked him about the most current practice for infiltrated contrast, and they did not recommend Hyaluronidase. It was an old practice that was not proven with practice or current literature.  When we took this to the Radiology Committee, the Radiologist also agreed to recommend warm compresses, observation, and vascular/plastics consults instead.