Here is a new problem I have encountered but unsure if I am looking at the right culprit: I had several days in which I was called to come see a PICC line having difficulty aspirating and flushing. Could go up and flush it a few times and it would be good. One of my assistants swore it was positional(?i.e. flushes easier when arm moved.) When the doctor heard about the problems, he ordered it discontinued. I noted that the anitbiotic that had just finished infusing was Rocephin and the main line it was infusing through was Lactated Ringers. I noted on the Rocephin bag there was a statement regarding not mixing LR with Rocephin. The FDA retracted the statement in April 2009 that this was only a concern for neonates. Could the rocephin and LActated ringers have caused precipitate in the PICC? Anybody else have similar problems?