Out institution is writing a policy in regards to chemo extravasation and administration of Dexrazoxane infusion for extravasation of Anthracycline and prophylactically for cardiac protection pre transfusion of Anthracycline. The recommendations from ONS is to : 'Dexrazoxane should be infused over 1-2 hrs in a large vein in an area other than the extravasation if possible or distal to the extravasation site'. Can anyone tell me why this infusion needs to be 'in a large vein' and what defines a large vein. They are not saying centrally and yet do say to give distal to extravasation site in some cases and use opposite side in another statement. Is it pH - although it dilutes to a pH of ~ 7.0.
Any information would be appreciated,