The INS standard states that "The nurse should aspirate for a positive blood return from the vascular access device to confirm device patency prior to administration of parenteral medications and solutions." I agree that this is a very important step. My questions are: Do you aspirate every time if you are administering a medication more than daily? And, if you do aspirate and get blood in the needleless connector do you change the needleless connector every time? We are a pediatric home infusion company and so most of our medications administered in the home are given by a trained family member/caregiver. We do not teach them to aspirate prior to med administration. But, occasionally, a child will have an extended hours nurse in the home who gives the med and we have found that they are aspirating with each dose given ( every 4 hrs, for example) and not changing the needleless connector.