Our hospital is trying to reduce the occurence of PICC occlusions. One unit, who has had a very high occlusion rate in the past, has started hanging a KVO at 20ml/hr when patients are receiving a Morphine drip. Their occlusion rate has been zero for several months now. Is there any literature to support this practice? Is any other hospital using a practice similar to this? Also, could this be applied to a PICC that has several intermittent medications infusing, to help limit the amount of times you manipulate the catheter hub to flush before and after each medication with saline? We are aware that this method could not be used for any patient on restricted fluids.